Yulia is a Royal Society University Research Fellow; before moving to Britain she did her PhD in Academy of Science (Russia), and postdoctoral research at Rutgers University (USA).
Her group’s main research topic is the regulation of gene expression in various bacteria, including major human pathogens and cyanobacteria. Yulia’s group is working on basic mechanisms of transcription, the first stage of gene expression, and modes of action of antibiotics targeting this stage.
Photosynthetic cyanobacteria developed unique mechanisms to control gene expression in adaptation to day/night changes. The central control mechanism, which synchronizes gene expression with daily light cycles, is circadian clock. The clock sends the signals to the gene expression machinery to activate or repress target genes using network of regulators.
In the Portabolomics project, Yulia’s group is investigating circadian regulators, which switch genes on/off at the level of transcription. Ultimately, they aim to design elements of circadian control to use as tools for Synthetic Biology applications in industrially important microorganisms.