The Murray Lab studies bacterial DNA replication initiation in the model organism Bacillus subtilis. Using a combination of genetics, cell biology, molecular biology, and biochemistry, they are investigating the structure of the bacterial chromosome origin (oriC) and the activity of the master DNA replication initiation protein DnaA. One of the tools the group has developed is an artificial chromosome origin that allows them to bypass the normally essential endogenous factors. They are keen to explore the utility of more sophisticated synthetic replication systems, both for fundamental understanding of DNA replication and for exploitation in biotechnology.
Tel: 0191 208 3233